In a severely obstructed AK with an initial relative function of 7, they found a significant increase to 31 at 12 wk can you take viagra twice in one day While none of the analyzed patient characteristics such as age, BMI, ECOG, or the number of concomitant medications had a significant influence on therapy persistence, AEs in the early treatment phase and patient noncompliance due to illness and forgetfulness correlate with nonpersistence